Histopathological changes due to Gold Kushta in kidneys of Wistar Rats.

Objective: To evaluate the histopathological effects of Gold Kushta in kidneys Wistar rats. Study Design: Experimental study. Setting: Department Pathology, Sahiwal Medical College, Sahiwal. Period: 1st July 2019 till 31st December 2019. Material & Methods: The experimental study was conducted on a total 28 wistar rats 6 – 8 weeks age and weighing 200 250 grams which were then randomly divided into 4 groups each containing 7 labelled as G I, II, III IV. These given preparations gold form kushta for period weeks. pellets. Group I taken Control, II single dose 0.15 mg double 0.3mg alternate days. IV BSA (bovine serum albumin) 75mg (250mg/kg body wt) at start experiment 0.3 Histopathological changes seen mesangium, capillary walls tubules Results: All parameters normal 1 while Groups mesangial proliferation increased more diffuse with thickened walls. cellularity but it all Mesangial greatest None had epithelial necrosis, dilatation or casts. Epithelial protein casts most Conclusion: Thus, has detrimental over are thus by concomitant exposure to bovine albumin.